THE BEREITSCHAFTSPOTENTIAL IS ABNORMAL IN PARKINSON'S DISEASE
Identifieur interne : 002799 ( Main/Exploration ); précédent : 002798; suivant : 002800THE BEREITSCHAFTSPOTENTIAL IS ABNORMAL IN PARKINSON'S DISEASE
Auteurs : J. P. R. Dick [Royaume-Uni] ; J. C. Rothwell [Royaume-Uni] ; B. L. Day [Royaume-Uni] ; R. Cantello [Royaume-Uni] ; O. Buruma [Royaume-Uni] ; M. Gioux [Royaume-Uni] ; R. Benecke [Royaume-Uni] ; A. Berardelli [Royaume-Uni] ; P. D. Thompson [Royaume-Uni] ; C. D. Marsden [Royaume-Uni]Source :
- Brain [ 0006-8950 ] ; 1989-02.
Abstract
The average Bereitschaftspotential (BP) preceding a rapid, self-paced voluntary extension movement of the index finger was recorded from 6 scalp locations in 14 patients with Parkinson's disease who had been withdrawn from their normal drug therapy for at least 12 h before testing. The amplitude of the potential was measured at the peak negativity (Nl) and 650 ms prior to this (NSI), and compared with that recorded in a group of 12 age-matched control subjects. The Nl amplitude was the same as in the normals, but the NS1 component was smaller in the patients, especially in midline leads As a result, the rise in the BP between the peak NS1 and Nl component (termed NS2) was larger in the patient group. The NS1 component of the BP is thought to reflect preparatory activity in the supplementary motor area (SMA) of cortex. Since the basal ganglia provide a major source of afferent input to SMA, the reduction in NS1 in the patients probably results from inadequate basal ganglia activation of SMA. The larger NS2 component may reflect extra activity in other brain areas to compensate for the reduced SMA activity.
Url:
DOI: 10.1093/brain/112.1.233
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>THE BEREITSCHAFTSPOTENTIAL IS ABNORMAL IN PARKINSON'S DISEASE</title><author><name sortKey="Dick, J P R" sort="Dick, J P R" uniqKey="Dick J" first="J. P. R." last="Dick">J. P. R. Dick</name></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name></author><author><name sortKey="Cantello, R" sort="Cantello, R" uniqKey="Cantello R" first="R." last="Cantello">R. Cantello</name></author><author><name sortKey="Buruma, O" sort="Buruma, O" uniqKey="Buruma O" first="O." last="Buruma">O. Buruma</name></author><author><name sortKey="Gioux, M" sort="Gioux, M" uniqKey="Gioux M" first="M." last="Gioux">M. Gioux</name></author><author><name sortKey="Benecke, R" sort="Benecke, R" uniqKey="Benecke R" first="R." last="Benecke">R. Benecke</name></author><author><name sortKey="Berardelli, A" sort="Berardelli, A" uniqKey="Berardelli A" first="A." last="Berardelli">A. Berardelli</name></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5168090868D0F1098E57114A9C86FE4E3D15F3D5</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1093/brain/112.1.233</idno><idno type="url">https://api.istex.fr/document/5168090868D0F1098E57114A9C86FE4E3D15F3D5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001C56</idno><idno type="wicri:Area/Main/Curation">001984</idno><idno type="wicri:Area/Main/Exploration">002799</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">THE BEREITSCHAFTSPOTENTIAL IS ABNORMAL IN PARKINSON'S DISEASE</title><author><name sortKey="Dick, J P R" sort="Dick, J P R" uniqKey="Dick J" first="J. P. R." last="Dick">J. P. R. Dick</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Cantello, R" sort="Cantello, R" uniqKey="Cantello R" first="R." last="Cantello">R. Cantello</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Buruma, O" sort="Buruma, O" uniqKey="Buruma O" first="O." last="Buruma">O. Buruma</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Gioux, M" sort="Gioux, M" uniqKey="Gioux M" first="M." last="Gioux">M. Gioux</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Benecke, R" sort="Benecke, R" uniqKey="Benecke R" first="R." last="Benecke">R. Benecke</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Berardelli, A" sort="Berardelli, A" uniqKey="Berardelli A" first="A." last="Berardelli">A. Berardelli</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1989-02">1989-02</date><biblScope unit="volume">112</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="233">233</biblScope><biblScope unit="page" to="244">244</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">5168090868D0F1098E57114A9C86FE4E3D15F3D5</idno><idno type="DOI">10.1093/brain/112.1.233</idno><idno type="ArticleID">112.1.233</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The average Bereitschaftspotential (BP) preceding a rapid, self-paced voluntary extension movement of the index finger was recorded from 6 scalp locations in 14 patients with Parkinson's disease who had been withdrawn from their normal drug therapy for at least 12 h before testing. The amplitude of the potential was measured at the peak negativity (Nl) and 650 ms prior to this (NSI), and compared with that recorded in a group of 12 age-matched control subjects. The Nl amplitude was the same as in the normals, but the NS1 component was smaller in the patients, especially in midline leads As a result, the rise in the BP between the peak NS1 and Nl component (termed NS2) was larger in the patient group. The NS1 component of the BP is thought to reflect preparatory activity in the supplementary motor area (SMA) of cortex. Since the basal ganglia provide a major source of afferent input to SMA, the reduction in NS1 in the patients probably results from inadequate basal ganglia activation of SMA. The larger NS2 component may reflect extra activity in other brain areas to compensate for the reduced SMA activity.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dick, J P R" sort="Dick, J P R" uniqKey="Dick J" first="J. P. R." last="Dick">J. P. R. Dick</name></region><name sortKey="Benecke, R" sort="Benecke, R" uniqKey="Benecke R" first="R." last="Benecke">R. Benecke</name><name sortKey="Berardelli, A" sort="Berardelli, A" uniqKey="Berardelli A" first="A." last="Berardelli">A. Berardelli</name><name sortKey="Buruma, O" sort="Buruma, O" uniqKey="Buruma O" first="O." last="Buruma">O. Buruma</name><name sortKey="Cantello, R" sort="Cantello, R" uniqKey="Cantello R" first="R." last="Cantello">R. Cantello</name><name sortKey="Day, B L" sort="Day, B L" uniqKey="Day B" first="B. L." last="Day">B. L. Day</name><name sortKey="Gioux, M" sort="Gioux, M" uniqKey="Gioux M" first="M." last="Gioux">M. Gioux</name><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002799 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002799 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5168090868D0F1098E57114A9C86FE4E3D15F3D5
|texte= THE BEREITSCHAFTSPOTENTIAL IS ABNORMAL IN PARKINSON'S DISEASE
}}
| This area was generated with Dilib version V0.6.23. |  |